E-MEXP-13 - Transcription profiling of human VHL treated A498 renal cancer cells
Released on 18 September 2003, last updated on 27 March 2012
A498 cells, established from a clear cell renal cell cancer of a 52 years old male patient, were obtained from ATCC and maintained in DMEM supplemented with 10% fetal calf serum (FCS). This cell line does not express functional VHL. A498 subclones stably transfected with HA-pVHL30 or control plasmid have been described and were maintained in 0.5 mg/ml G418.
transcription profiling by array, transcript identification
Edward J Oakeley <firstname.lastname@example.org>, Holger Moch, Jitka Sulitkova, Joanna Lisztwan, Peter Staller, Wilhelm Krek
The von Hippel-Lindau tumour suppressor protein pVHL negatively regulates CXCR4 chemokine receptor expression. Edward Oakeley,Wilhelm Krek,Peter Staller,Jitka Sulitkova,Joanna Lisztwan,Holger Moch.