E-MEXP-1190 - Transcription profiling time series of kidney, liver and spleen from three strains of mice infected with Trypanosoma congolense to investigate strain differences in susceptibility

Released on 21 August 2007, last updated on 19 August 2014
Mus musculus
Samples (166)
Array (1)
Protocols (7)
In this experiment, mice from 3 strains A/J, Balb C and C57Bl6 were infected with Trypanosoma Congolense, IL1180 clone, African sleeping sickness, a disease which affects cattle in sub-saharan Africa. These mouse strains were chosen because they are a model for tolerance to infection in cattle, with A/J and Balb B being highly susceptible, and C57Bl6 being somewhat more tolerant to infection. Three tissues Kidney Liver and Spleen were harvested from cohorts at various timepoints: 0 (naive), 3, 7, 9 and 17 days post infection. Each condition thus comprises: Time, Tissue, Strain. For each condition, RNA extracts from individuals were pooled (5 per pool) prior to hybridisation.
Experiment types
transcription profiling by array, co-expression, disease state, organism part comparison, replicate, strain or line, time series
A systematic strategy for large-scale analysis of genotype phenotype correlations: identification of candidate genes involved in African trypanosomiasis. Fisher, Paul; Hedeler, Cornelia; Wolstencroft, Katherine; Hulme, Helen; Noyes, Harry; Kemp, Stephen; Stevens, Robert; Brass, Andrew. , Europe PMC 17709344
A comprehensive genetic analysis of candidate genes regulating response to Trypanosoma congolense infection in mice. Goodhead I, Archibald A, Amwayi P, Brass A, Gibson J, Hall N, Hughes MA, Limo M, Iraqi F, Kemp SJ, Noyes HA. :e880 (2010), Europe PMC 21085469
Mechanisms controlling anaemia in Trypanosoma congolense infected mice. Noyes HA, Alimohammadian MH, Agaba M, Brass A, Fuchs H, Gailus-Durner V, Hulme H, Iraqi F, Kemp S, Rathkolb B, Wolf E, de Angelis MH, Roshandel D, Naessens J. :e5170 (2009), Europe PMC 19365556