E-MEXP-1025 - Transcription profiling by array of spinal cord from rats with experimental autoimmune encephalomyelitis
Released on 15 May 2007, last updated on 2 May 2014
The intention of the study was to examine the spinal cord gene expression at three different EAE disease points and to compare them with three nonimmunised, healthy rats. We immunised female DA rats with recombinant MOG-protein and sacrificed them during the acute phase of EAE defined as the first EAE attack leading to a clinical score of at least three, in the recovery phase in which the rats have begun to gain weight after the acute phase and in the relapsing phase - rats belonging to this group have been sacrificed while they were in the peak of the first relaps. Three healthy control rats, three from the acute phase of EAE (day 11 and 12 after EAE induction), three from the recovery phase (day 13 and 14 after EAE induction) and four rats from the relapsing phase (day 24 and 25 after EAE induction) have been finally sacrificed for the study.
transcription profiling by array, co-expression, disease state design
Novel role for SLPI in MOG-induced EAE revealed by spinal cord expression analysis. Mueller AM, Pedre X, Stempfl T, Kleiter I, Couillard-Despres S, Aigner L, Giegerich G, Steinbrecher A. , Europe PMC 18501024
Inhibition of hyaluronan synthesis protects against central nervous system (CNS) autoimmunity and increases CXCL12 expression in the inflamed CNS. Mueller AM, Yoon BH, Sadiq SA. :22888-22899 (2014), Europe PMC 24973214