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E-GEOD-9971 - Transcription profiling on non-small cell lung cancer samples reveals CYP3A5 gene expression is associated with early recurrence

Status
Submitted on 19 December 2007, released on 14 December 2009, last updated on 2 May 2014
Organism
Homo sapiens
Samples (27)
Array (1)
Protocols (5)
Description
Study to identify genes associated with NSCLC recurrence in patients not receiving adjuvant chemotherapy. Purpose: Recent clinical trials suggest improvement in survival with adjuvant chemotherapy in non-small cell lung cancer (NSCLC). This study's aim is to identify genes associated with NSCLC recurrence in patients not receiving adjuvant chemotherapy. Experimental design: Banked NSCLC tumors of patients who underwent resection of stage Ia-IIIb disease were identified. Patients were stratified into two groups: recurrent (R, n=11) or non-recurrent (NR, n=16) 2 years after surgery. Microarray profiling and Cox multivariate analysis were performed. Conclusion: Increased CYP3A5 gene expression correlates with NSCLC recurrence and promotes proliferation through mechanisms that may involve, in part, CYP3A5 epoxygenase activity. Experiment Overall Design: comparison of gene expression profiles for recurrent and non-recurrent cancer
Experiment types
transcription profiling by array, unknown experiment type
Contact
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-GEOD-9971.idf.txt
Sample and data relationshipE-GEOD-9971.sdrf.txt
Raw data (1)E-GEOD-9971.raw.1.zip
Processed data (1)E-GEOD-9971.processed.1.zip
Array designA-AFFY-33.adf.txt
R ExpressionSetE-GEOD-9971.eSet.r
Links