Please note that we have stopped the regular imports of Gene Expression Omnibus (GEO) data into ArrayExpress. This may not be the latest version of this experiment.
E-GEOD-9712 - Transcription profiling of human radioresistant tumor xenografts from athymic nude mice to detect genes differentially expressed in radioresistant tumors
Submitted on 28 November 2007, released on 16 June 2008, last updated on 27 March 2012
Nu61, a radiation-resistant human tumor xenograft, was selected from a parental radiosensitive tumor SCC-61 by eight serial cycles of passage in athymic nude mice and in vivo irradiation. Obtained tumors were profiled using Affymetrix U133A arrays. Most abundant gene pattern associated with radioresistant phenotype was presented by IFN-inducible, Stat1-dependent pathway Experiment Overall Design: Obtained tumors were established as xenografts in nude mice. RNA were purified from each xenograft, normalized by concentration and three samples of RNA from each group were pooled for hybridization with each array. Three arrays were used for each group.
transcription profiling by array, unknown experiment type
STAT1 is overexpressed in tumors selected for radioresistance and confers protection from radiation in transduced sensitive cells. Nikolai N Khodarev, Michael Beckett, Edwardine Labay, Thomas Darga, Bernard Roizman, Ralph R Weichselbaum. Proc Natl Acad Sci U S A 101(6):1714-9 (2004)