E-GEOD-8682 - Transcription profiling of mouse 3T3-L1 adipocyte tissue culture treated with tunicamycin
Submitted on 3 August 2007, released on 16 June 2008, last updated on 27 March 2012
Tunycamcin induces UPR/ISR and Inflammation in mouse 3T3-L1 adipocyte tissue culture. The early transcriptome changes were analyzed using high-density microarrays to better characterize the signaling pathways responding to tunicamycin, to be compared with similar experiments with CLA as the treatment. Their gene expression responses between 4 to 12 hr after treatment showed a common set of early gene expression changes indicative of a UPR/Inflammation stress response. Experiment Overall Design: Mouse 3T3-L1 RNA for each time point was isolated from control and treatment samples for analysis on microarrays with two biological reps.
transcription profiling by array, unknown experiment type
Trans-10, cis-12 conjugated linoleic acid activates the integrated stress response pathway in adipocytes. P Christopher LaRosa, Jean-Jack M Riethoven, Han Chen, Yuannan Xia, You Zhou, Mei Chen, Jess Miner, Michael E Fromm. Physiol Genomics 31(3):544-53 (2007)