E-GEOD-8681 - Transcription profiling of mouse 3T3-L1 adipocyte tissue culture treated with CLA

Submitted on 3 August 2007, released on 16 June 2008, last updated on 27 March 2012
Mus musculus
Samples (25)
Array (1)
Protocols (4)
Trans-10, Cis-12 conjugated linoleic acid (t10c12 CLA) causes fat loss in mouse 3T3-L1 adipocyte tissue culture. The early transcriptome changes were analyzed using high-density microarrays to better characterize the signaling pathways responding to t10c12 CLA. Their gene expression responses between 4 to 24 hr after treatment showed a common set of early gene expression changes indicative of an integrated stress response (ISR). Experiment Overall Design: Mouse 3T3-L1 RNA for each time point was isolated from control and treatment samples for analysis on microarrays with two to four biological reps.
Experiment types
transcription profiling by array, unknown experiment type
Trans-10, cis-12 conjugated linoleic acid activates the integrated stress response pathway in adipocytes. P Christopher LaRosa, Jean-Jack M Riethoven, Han Chen, Yuannan Xia, You Zhou, Mei Chen, Jess Miner, Michael E Fromm. Physiol Genomics 31(3):544-53 (2007)
Investigation descriptionE-GEOD-8681.idf.txt
Sample and data relationshipE-GEOD-8681.sdrf.txt
Raw data (1)E-GEOD-8681.raw.1.zip
Processed data (1)E-GEOD-8681.processed.1.zip
Array designA-AFFY-45.adf.txt
R ExpressionSetE-GEOD-8681.eSet.r