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E-GEOD-84422 - Molecular Signatures Underlying Selective Regional Vulnerability to Alzheimer's Disease

Released on 19 August 2016, last updated on 12 September 2016
Homo sapiens
Samples (2004)
Arrays (3)
Protocols (7)
Alzheimer's disease (AD) is the most common form of dementia, characterized by progressive cognitive impairment and neurodegeneration as a result of abnormal neuronal loss. To elucidate the molecular systems associated with AD, we characterized the gene expression changes associated with multiple clinical and neuropathological traits in 1,053 postmortem brain samples across 19 brain regions from 125 persons dying with varying severities of dementia and variable AD-neuropathology severities. 125 human brains were accessed from the Mount Sinai/JJ Peters VA Medical Center Brain Bank (MSBB). This brain resource was assembled after applying stringent inclusion/exclusion criteria and represents the full spectrum of clinical and neuropathological disease severity in the absence of discernable non-AD neuropathology. RNA samples from 19 brain regions isolated from the 125 MSBB specimens were collected and profiled using Affymetrix Genechip microarrays. There were 50 to 60 subjects per brain region with varying degrees of AD pathological abnormalities.
Experiment type
transcription profiling by array 
Bin Zhang <>, Katsel Pavel, Minghui Wang, Panos Roussos, Vahram Haroutunian