E-GEOD-8397 - Transcription profiling of human Parkinsons medial and substania nigra
Released on 16 June 2008, last updated on 27 March 2012
Affymetrix HG_U133 array sets (A and B chips) were used to determine the whole genome transcription profile of clinically documented and neuropathologically confirmed cases of sporadic Parkinson's disease as well as controls. Experiment Overall Design: Post mortem brain tissue samples from Parkinson's disease and control cases (substantia nigra, split into medial and lateral portions, and frontal cortex) were prepared for this study. In total, 47 individual tissue samples were analyzed using one A and one B GeneChip per sample, i.e. 15 samples of medial parkinsonian SN, 9 samples of lateral parkinsonian SN, 8 medial nigra control samples and 7 lateral nigra control samples. Lateral and medial nigra samples were from the same cases. In addition, frontal cerebral cortex was analyzed in five of the PD cases and in three of the controls (Neurogenetics 2006 7: 1–11; Acta Neuropathologica (Berlin) 2007 113: 253-263
transcription profiling by array, unknown experiment type
Linda B. Moran
Whole genome expression profiling of the medial and lateral substantia nigra in Parkinson's disease. L B Moran, D C Duke, M Deprez, D T Dexter, R K B Pearce, M B Graeber.