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E-GEOD-80315 - Boxer dataset for genome-wide association study of modifiers of risk of canine degenerative myelopathy in dogs homozygous for SOD1 mutation

Status
Released on 1 June 2016, last updated on 4 June 2016
Organism
Canis lupus familiaris
Samples (25)
Array (1)
Protocols (5)
Description
Degenerative myelopathy (DM) is a canine disease very similar to amyotrophic lateral sclerosis (ALS) in humans. We previously showed that DM is a promising model for ALS, as genome-wide association identified a mutation in SOD1, a known ALS gene. In this study, we identify a modifier gene, SP110, which strongly affects overall disease risk and age-of-onset in Pembroke Welsh corgis at risk of DM. Dissecting the complex genetics of this disease in a model organism may lead to new insights about risk and progression in both canine and human patients. 15 DM-affected and 10 unaffected Boxers homozygous for SOD1 mutation genotyped using the Illumina CanineHD array (~170,000 SNPs genomewide)
Experiment type
genotyping by array 
Contacts
Kerstin Lindblad-Toh <geo@ncbi.nlm.nih.gov>, Emma L Ivansson, Katherine J Megquier
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-GEOD-80315.idf.txt
Sample and data relationshipE-GEOD-80315.sdrf.txt
Processed data (1)E-GEOD-80315.processed.1.zip
Additional data (1)E-GEOD-80315.additional.1.zip
Array designA-GEOD-17481.adf.txt
Links