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E-GEOD-80119 - Effects of exendin-4 in Brunner's glands of male GLP-1R-/- and wild-type control mice

Status
Released on 1 July 2016, last updated on 11 July 2016
Organism
Mus musculus
Samples (18)
Array (1)
Protocols (5)
Description
To gain insight into the biological functions of the highly expressed GLP-1R in Brunner’s glands, transcriptome analyses were conducted in male GLP-1R-/- and wild-type control mice. Analyses were performed 6 hours after a single s.c. dose of exendin-4 (1.0mg/kg s.c.), following 18 hours of two doses of exendin-4 (1.0 mg/kg s.c., administered at 0 and 9 hours), and in untreated controls. Brunner’s glands were isolated by laser capture micro dissection and extracted total RNA was used for microarray profiling. A total of 18 samples consisting of laser captured microdissected Brunner's glands from individual male GLP-1R-/- and wild-type (CD-1) mice. Before the isolation of Brunner's glands, mice were dosed with exendin-4 for 6 and 18 hours. The extracted total RNA from Brunner's glands were compared by full transcriptome profiling.
Experiment type
transcription profiling by array 
Contacts
Klaus Stensgaard Frederiksen <geo@ncbi.nlm.nih.gov>, Claus H Bang-Berthelsen, Klaus S Frederiksen, Lasse Folkersen, Rolf Søkilde
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-GEOD-80119.idf.txt
Sample and data relationshipE-GEOD-80119.sdrf.txt
Raw data (1)E-GEOD-80119.raw.1.zip
Processed data (1)E-GEOD-80119.processed.1.zip
Array designA-GEOD-20766.adf.txt
Links