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E-GEOD-7877 - Effect of acute creatine monohydrate supplementation on skeletal muscle transcriptome

Status
Submitted on 22 May 2007, released on 11 June 2010, last updated on 2 May 2014
Organism
Homo sapiens
Samples (24)
Array (1)
Protocols (7)
Description
Expression profiling of vastus lateralis muscle of young, healthy, non-obese men supplemented with creatine monohydrate vs. placebo for 10 days. Results identify transcriptional pathways activated in skeletal muscles as a result of acute creatine monohydrate supplementation. Keywords: Supplementation response. In a randomized, placebo-controlled, crossover, double-blind design, 12 young, healthy, non-obese men were supplemented with either a placebo or creatine monohydrate (loading phase, 20 g/d x 3 d; maintenance phase, 5 g/d x 7 d) for 10 d. Following a 28 day washout period, subjects were put on the alternate supplementation for 10 days. Muscle biopsies of the vastus lateralis were obtained and were assessed for global mRNA expression using cDNA microarrays.
Experiment type
transcription profiling by array 
Contacts
Adeel Safdar <safdars@mcmaster.ca>, A Safdar, M A Tarnopolsky, N Yardley, R Snow, S Melov
Citation
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-GEOD-7877.idf.txt
Sample and data relationshipE-GEOD-7877.sdrf.txt
Raw data (1)E-GEOD-7877.raw.1.zip
Processed data (1)E-GEOD-7877.processed.1.zip
Array designA-GEOD-5216.adf.txt
R ExpressionSetE-GEOD-7877.eSet.r
Links