E-GEOD-7861 - Angiogenesis study of Gd@C82(OH)22 nanoparticle
Submitted on 20 May 2007, released on 1 April 2009, last updated on 2 May 2014
Homo sapiens, Mus musculus
we report a novel nanomedicine (Gd@C82(OH)22 ) effectively inhibit human breast tumor growth by antiangiogenesis in vivo. To further identify which angiogenic factor(s) were affected on mRNA level, the "RT² Profiler™ PCR Array Mouse Angiogenesis (APMM-024, SuperArray Bioscience Corporation)" was used. Keywords: nanomedicine, Gd@C82(OH)22, angiogenesis, MCF-7, breast cancer In the experimental group, the tumor bearing mice were administered intraperitoneally (i.p.) [Gd@C82(OH)22]n saline solution once a day at the dose of 2.5mM/kg, after the tumor tissue implantation into the animal for 7 days, continuing until the mice were sacrificed. The 0.9% saline soultion was used as control. At the end of the experiment, parts of the tumor tissue was collected, and further be analyzed by PCR-array.
transcription profiling by array
Huan Meng <email@example.com>, Chengcheng Zhang, Chunying Chen, Feng Zhao, Gengmei Xing, Hao Lei, Hui Yuan, Ning Zhang, Xingjie Liang, Xuxia Wang, Yuliang Zhao, Zhen Chen