E-GEOD-7793 - Transcription profiling of mouse kidney treated with with vancomycin to assess nephrotoxicity

Status
Submitted on 14 May 2007, released on 15 June 2008, last updated on 10 June 2011
Organism
Mus musculus
Samples (51)
Array (1)
Protocols (7)
Description
The glycopeptide antibiotic vancomycin (VCM) represents one of the last lines of defense against methicillin-resistant Staphylococcus aureus infections. However, vancomycin is nephrotoxic, but the mechanism of toxicity is still unclear. The goal of this study was twofold: (1) gain insights into the molecular mechanisms of vancomycin nephrotoxicity at the genomic level and (2) evaluate potential biomarkers (gene expression profiles) of vancomycin-induced kidney injury Experiment Overall Design: Groups of 6 female BALB/c mice were treated with 7 daily iv or ip doses of vancomycin (50, 200, and 400 mg/kg) or saline, and sacrificed on Day 8
Experiment types
transcription profiling by array, unknown experiment type
Contact
Hanna Ng
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-GEOD-7793.idf.txt
Sample and data relationshipE-GEOD-7793.sdrf.txt
Raw data (1)E-GEOD-7793.raw.1.zip
Processed data (1)E-GEOD-7793.processed.1.zip
Array designA-AFFY-45.adf.txt
R ExpressionSetE-GEOD-7793.eSet.r
Links