E-GEOD-7763 - Transcription profiling by array of 8 adult and 2 larval Drosophila tissues
Released on 13 March 2008, last updated on 2 May 2014
A new online resource (flyatlas.org) provides the most comprehensive view yet of expression in multiple tissues of Drosophila. Meta-analysis of the data reveals that a significant fraction ofthe genome is expressed with great tissue specificity in the adult, demonstrating the need for the functional genomic community to embrace a wider range of functional phenotypes. Well-known developmental genes are often re-used in surprising tissues in the adult, suggesting new functions. The homologues of many human genetic disease loci show selective expression in Drosophila tissues with function analogous to the affected tissues in the cognate human disease, providing a useful filter for potential candidate genes. Experiment Overall Design: FlyAtlas is composed of data covering 8 distinct adult tissues (brain, head, midgut, Malpighian tubules,hindgut, testis, ovary, male accessory glands) so far, together with two larval tissues (tubule, fat body), each run with 4 replicates on Affymetrix Dros Genome 2 chips (with probesets for 18770 transcripts), and compared with a matched whole-fly sample.
transcription profiling by array, co-expression, organism part comparison
Using FlyAtlas to identify better Drosophila melanogaster models of human disease. Venkateswara R Chintapalli, Jing Wang, Julian A T Dow. , Europe PMC 17534367