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E-GEOD-7640 - Transcription profiling of rat heart left ventricle after exercise to investigate the role of exercise as a known protective factor against cardiovascular morbidity and mortality

Status
Released on 9 April 2008, last updated on 2 May 2014
Organism
Rattus norvegicus
Samples (20)
Array (1)
Protocols (6)
Description
Physical exercise training is a known protective factor against cardiovascular morbidity and mortality. Nevertheless, the underlying specific molecular mechanisms still remain uncompletely explored. To identify molecular mechanisms by which exercise training induces this favorable phenotype a genomic approach was used in an animal model of mild exercise previously demonstrated by our group to induce cardioprotection. Our data indicate that mild exercise by inducing no or few permanent changes in gene expression profile is able to determine cardioprotection without induction of cardiac hypertrophy. Experiment Overall Design: We investigated the gene expression profile by Affymetrix technology (230 2.0 GeneChip rat genome array) induced by mild exercise training (treadmill running: 25 m/min, 10% incline, 1 h/day, 3 days/week, 10 weeks) on left ventricle (LV) of exercise-trained (n=10) and sedentary control (n=10) rats.
Experiment types
transcription profiling by array, unknown experiment type
Contact
Betti Giusti
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-GEOD-7640.idf.txt
Sample and data relationshipE-GEOD-7640.sdrf.txt
Raw data (1)E-GEOD-7640.raw.1.zip
Processed data (1)E-GEOD-7640.processed.1.zip
Additional data (1)E-GEOD-7640.additional.1.zip
Array designA-AFFY-43.adf.txt
R ExpressionSetE-GEOD-7640.eSet.r
Links