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E-GEOD-76397 - Gene expression signatures for murine alveolar type II lung epithelial cells after tumor bearing

Released on 10 August 2016, last updated on 13 August 2016
Mus musculus
Samples (4)
Array (1)
Protocols (6)
To determine the influence of primary tumors on pre-metastatic lungs, we have employed whole genome microarray expression profiling as a discovery platform to identify gene signatures of alveolar type II epithelial cells (AT-II) in TLR3 deficient mice (Tlr3-/-) and wide-type (WT) littermates with tumor bearing. We subcutaneously inoculated Tlr3-/- and WT mice with Lewis lung carcinoma (LLC). Two weeks later, lung tissues from Tlr3-/- and WT mice were dissociated and AT-II cells were sorted. AT-II cells from mice without tumor bearing were set as controls. Primary tumor induced gene expression in AT-II cells from Tlr3-/- and WT mice was measured at 2 weeks after tumor inoculation subcutaneously. AT-II cells from mice without tumor bearing were set as controls.
Experiment type
transcription profiling by array 
Liu Yanfang <>, Xuetao Cao, Yanfang Liu
Investigation descriptionE-GEOD-76397.idf.txt
Sample and data relationshipE-GEOD-76397.sdrf.txt
Raw data (1)
Processed data (1)
Array designA-MEXP-724.adf.txt