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E-GEOD-74659 - SCL and LMO1 reprogram thymocytes into self-renewing cells

Status
Released on 5 November 2015, last updated on 1 December 2015
Organism
Mus musculus
Samples (6)
Array (1)
Protocols (7)
Description
The SCL and LMO1 oncogenic transcription factors reprogram thymocytes into self-renewing pre-leukemic stem cells (pre-LSCs). Here we report that SCL directly interacts with LMO1 to activate the transcription of a self-renewal program coordinated by LYL1. Gene expression profiles of thymocytes from SCL-LMO1 transgenic and age-matched non transgenic Cd3ε-/- mice were compared to identify candidate genes that confer self-renewal capability to pre-leukemic thymocytes.
Experiment type
transcription profiling by array 
Contacts
Mathieu Tremblay <mathieu.tremblay5@mcgill.ca>, M Tremblay, S Lemieux, T Hoang, V Veiga
Citation
SCL, LMO1 and Notch1 reprogram thymocytes into self-renewing cells. Gerby B, Tremblay CS, Tremblay M, Rojas-Sutterlin S, Herblot S, H�bert J, Sauvageau G, Lemieux S, L�cuyer E, Veiga DF, Hoang T. , PMID:25522233
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-GEOD-74659.idf.txt
Sample and data relationshipE-GEOD-74659.sdrf.txt
Raw data (1)E-GEOD-74659.raw.1.zip
Processed data (1)E-GEOD-74659.processed.1.zip
Array designA-AFFY-23.adf.txt
Links