Please note that we have stopped the regular imports of Gene Expression Omnibus (GEO) data into ArrayExpress. This may not be the latest version of this experiment.
E-GEOD-74659 - SCL and LMO1 reprogram thymocytes into self-renewing cells
Released on 5 November 2015, last updated on 1 December 2015
The SCL and LMO1 oncogenic transcription factors reprogram thymocytes into self-renewing pre-leukemic stem cells (pre-LSCs). Here we report that SCL directly interacts with LMO1 to activate the transcription of a self-renewal program coordinated by LYL1. Gene expression profiles of thymocytes from SCL-LMO1 transgenic and age-matched non transgenic Cd3ε-/- mice were compared to identify candidate genes that confer self-renewal capability to pre-leukemic thymocytes.
transcription profiling by array
Mathieu Tremblay <email@example.com>, M Tremblay, S Lemieux, T Hoang, V Veiga
SCL, LMO1 and Notch1 reprogram thymocytes into self-renewing cells. Gerby B, Tremblay CS, Tremblay M, Rojas-Sutterlin S, Herblot S, Hï¿½bert J, Sauvageau G, Lemieux S, Lï¿½cuyer E, Veiga DF, Hoang T. , PMID:25522233