E-GEOD-7378 - Transcription profiling of human age-dichotomized ER+, N0 breast tumors reveals enhanced NF kappa B and AP-1 activity associated with antiestrogen resistant breast caner

Status
Submitted on 27 March 2007, released on 15 June 2008, last updated on 27 March 2012
Organism
Homo sapiens
Samples (54)
Array (1)
Protocols (4)
Description
Signaling pathways that converge on two different transcription factor complexes, NFκB and AP-1, have been identified in estrogen receptor (ER)-positive breast cancers resistant to the antiestrogen, tamoxifen. In this study, biomarkers co-ordinately up-regulated by NFKB and AP-1 with prognositic significance are identified in a largely TAM-treated set of ER+ node negative breast cancers. The prognostic value with respect to age is also investigated. Experiment Overall Design: 54 ER+ node negative breast tumors with known clinical outcome were analyzed. Genes co-ordinately regulated by NFKB and AP1from literature are identified from a significant gene set obtained through a minimum variation filter. Biomarker expression is used to dichotomize samples into high vs. low expressors to determine prognostic value
Experiment types
transcription profiling by array, unknown experiment type
Contact
Citation
Enhanced NF kappa B and AP-1 transcriptional activity associated with antiestrogen resistant breast cancer. Yamei Zhou, Christina Yau, Joe W Gray, Karen Chew, Shanaz H Dairkee, Dan H Moore, Urs Eppenberger, Serenella Eppenberger-Castori, Christopher C Benz. BMC Cancer 7:59 (2007)
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-GEOD-7378.idf.txt
Sample and data relationshipE-GEOD-7378.sdrf.txt
Raw data (1)E-GEOD-7378.raw.1.zip
Processed data (1)E-GEOD-7378.processed.1.zip
Array designA-AFFY-76.adf.txt
R ExpressionSetE-GEOD-7378.eSet.r
Links