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E-GEOD-72815 - Effects of Age and Estrogen on Skeletal Gene Expression in Humans as Assessed by RNA Sequencing

Status
Released on 9 September 2015, last updated on 12 September 2015
Organism
Homo sapiens
Samples (58)
Protocols (1)
Description
Here we present an RNAseq analysis of human bone samples, obtained from iliac crest needle biopsies, to yield the first in vivo interrogation of all genes and pathways that may be altered in bone with aging and E therapy in humans. 58 healthy women were studied, including 19 young women (mean age ± SD, 30.3 ± 5.4 years), 19 old women (73.1 ± 6.6 years), and 20 old women treated with 3 weeks of E therapy (70.5 ± 5.2 years). Using generally accepted criteria (false discovery rate [q] < 0.10), aging altered a total of 678 genes and 12 pathways, including a subset known to regulate bone metabolism (e.g., Notch).
Experiment type
RNA-seq of coding RNA 
Contacts
David G Monroe, Sundeep Khosla
MINSEQE
Exp. designProtocolsVariablesProcessedSeq. reads
Files
Investigation descriptionE-GEOD-72815.idf.txt
Sample and data relationshipE-GEOD-72815.sdrf.txt
Additional data (1)E-GEOD-72815.additional.1.zip
Links