Please note that we have stopped the regular imports of Gene Expression Omnibus (GEO) data into ArrayExpress. This may not be the latest version of this experiment.
E-GEOD-72615 - Deficiency of multidrug resistance 2 contributes to cell transformation through oxidative stress
Released on 2 September 2015, last updated on 5 September 2015
Mdr2 is the transporter of phosphatidylcholine, which is an essential component of bile. Deficiency of mdr2 causes hepatic inflammation, liver fibrosis and hepatocellular carcinoma. Mdr2-/- MEFs show increased proliferation, spontaneous transformation and tumorigenesis. We used microarray to obtain genome-wide profiling of gene expression underlying the changes in mdr2-/- MEFs. MEFs derived from wt and mdr2-/- littermate embyos were subjected to passage according to 3T3 protocols. RNA was extracted from cells on passage 40 and hybridized on Affymetrix microarrays.
transcription profiling by array
Guillaume soubigou <email@example.com>, Ali Tebbi, Florence Levillayer, Guillaume Soubigou, Hugo Varet, Yu Wei