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E-GEOD-72615 - Deficiency of multidrug resistance 2 contributes to cell transformation through oxidative stress

Status
Released on 2 September 2015, last updated on 5 September 2015
Organism
Mus musculus
Samples (5)
Array (1)
Protocols (6)
Description
Mdr2 is the transporter of phosphatidylcholine, which is an essential component of bile. Deficiency of mdr2 causes hepatic inflammation, liver fibrosis and hepatocellular carcinoma. Mdr2-/- MEFs show increased proliferation, spontaneous transformation and tumorigenesis. We used microarray to obtain genome-wide profiling of gene expression underlying the changes in mdr2-/- MEFs. MEFs derived from wt and mdr2-/- littermate embyos were subjected to passage according to 3T3 protocols. RNA was extracted from cells on passage 40 and hybridized on Affymetrix microarrays.
Experiment type
transcription profiling by array 
Contacts
Guillaume soubigou <geo@ncbi.nlm.nih.gov>, Ali Tebbi, Florence Levillayer, Guillaume Soubigou, Hugo Varet, Yu Wei
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-GEOD-72615.idf.txt
Sample and data relationshipE-GEOD-72615.sdrf.txt
Raw data (1)E-GEOD-72615.raw.1.zip
Processed data (1)E-GEOD-72615.processed.1.zip
Additional data (1)E-GEOD-72615.additional.1.zip
Array designA-AFFY-130.adf.txt
Links