Please note that we have stopped the regular imports of Gene Expression Omnibus (GEO) data into ArrayExpress. This may not be the latest version of this experiment.

E-GEOD-71740 - Inhibitors of the histone lysine demethylase KDM1A are broadly efficacious in AML by evicting the enzyme from chromatin [RNA-Seq]

Status
Released on 10 February 2016, last updated on 12 February 2016
Organism
Homo sapiens
Samples (32)
Protocols (4)
Description
Investigating the effects of two different classes of KDM1A inhibitors on the transcriptome of AML cell lines 16 different samples with biological replicates. Treatment for 24 and 72 hours with an irreversible KDM1A inhibitor (RN-1) or a reversible KDM1A inhibitor (GSK690) or an inactive isomer of the latter (GSK690*).
Experiment type
RNA-seq of coding RNA 
Contacts
Barbara M Bryant <barbara.bryant@constellationpharma.com>, Charlie Hatton, John P McGrath, Patrick Trojer
Citation
Pharmacological inhibition of the histone lysine demethylase KDM1A suppresses the growth of multiple acute myeloid leukemia subtypes. McGrath JP, Williamson KE, Balasubramanian S, Odate S, Arora S, Hatton C, Edwards TM, O'Brian T, Magnuson S, Stokoe D, Daniels DL, Bryant BM, Trojer P. , PMID:26837761
MINSEQE
Exp. designProtocolsVariablesProcessedSeq. reads
Files
Investigation descriptionE-GEOD-71740.idf.txt
Sample and data relationshipE-GEOD-71740.sdrf.txt
Additional data (1)E-GEOD-71740.additional.1.zip
Links