Please note that we have stopped the regular imports of Gene Expression Omnibus (GEO) data into ArrayExpress. This may not be the latest version of this experiment.
E-GEOD-71628 - Global hepatic gene expression data from germ free and specific pathogen free male mice
Released on 20 February 2016, last updated on 27 February 2016
Liver clock regulates transcription of hepatic genes in response to feeding. To explore the possibility that the microbiome influences this process, we measured the liver transcriptome in normal mice (Specific Pathogen Free or SPF mice) and compared it to the transcriptome in mice lacking microbiota (Germ Free or GF mice) at different time points over 24h. We used microarrays to detail the global programme of gene expression in liver of GF and SPF 10-12 weeks-old male C57Bl/6 male mice. There are 40 liver samples, each from an individual mouse. The samples are from germ free mice (GF) and specific pathogen free mice (SPF). Mice of both types were sacrificed at four time points: Zeitgeber Time 0, 6, 12, and 18. There are five replicates per condition.
transcription profiling by array
Agata Korecka, Alexandra Montagner, Hervé Guillou, Sven Pettersson, Velmurugesan Arulampalam, Walter Wahli
Hepatic circadian clock oscillators and nuclear receptors integrate microbiome-derived signals. Montagner A, Korecka A, Polizzi A, Lippi Y, Blum Y, Canlet C, Tremblay-Franco M, Gautier-Stein A, Burcelin R, Yen YC, Je HS, Maha AA, Mithieux G, Arulampalam V, Lagarrigue S, Guillou H, Pettersson S, Wahli W. , PMID:26879573