Please note that we have stopped the regular imports of Gene Expression Omnibus (GEO) data into ArrayExpress. This may not be the latest version of this experiment.
E-GEOD-71421 - RNA-seq of coding RNA in primary human hematopoietic cells treated with UNC0638 or DMSO control
Released on 2 November 2015, last updated on 11 July 2016
Using UNC0638 and genetic assays to inhibit EHMT1/2 and derepress fetal hemoglobin in adult hematopoietic cells. RNA-Seq in primary adult human erythroid cells treated with UNC0638 or the vehicle control (DMSO) in biological triplicates.
RNA-seq of coding RNA, compound treatment design
John Krill-Burger <email@example.com>, Aline Renneville, Benjamin L Ebert, Bradley E Bernstein, Daniel E Bauer, David M Dorfman, Edward B Holson, Marie McConkey, Matthew C Canver, Peter Van Galen, Stuart H Orkin
EHMT1 and EHMT2 inhibition induces fetal hemoglobin expression. Renneville A, Van Galen P, Canver MC, McConkey M, Krill-Burger JM, Dorfman DM, Holson EB, Bernstein BE, Orkin SH, Bauer DE, Ebert BL. , PMID:26320100