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E-GEOD-70728 - Role of the histone demethylase KDM2B in hematopoietic homeostasis and malignancies [RNA-seq]

Status
Released on 22 February 2016, last updated on 27 February 2016
Organism
Mus musculus
Samples (4)
Protocols (3)
Description
Development of the hematopoietic system is dynamically controlled by the interplay of transcriptional and epigenetic networks to determine cellular identity. Those networks are critical for homeostasis and frequently dysregulated in leukemias. We identified histone demethylase Kdm2b as a critical regulator of definitive hematopoiesis and lineage specification of hematopoietic stem and progenitor cells (HSPCs). RNA sequencing in murine HSPCs and genome-wide chromatin immunoprecipitation studies in human leukemias revealed that Kdm2b regulates differentiation, lineage choice, cytokine signaling, and quiescence. Comparison of gene expression in wild-type and knockout HSPCs
Experiment type
RNA-seq of coding RNA 
Contacts
Alexandros Tzatsos, Yan Kai
Citation
MINSEQE
Exp. designProtocolsVariablesProcessedSeq. reads
Files
Investigation descriptionE-GEOD-70728.idf.txt
Sample and data relationshipE-GEOD-70728.sdrf.txt
Additional data (1)E-GEOD-70728.additional.1.zip
Links