Please note that we have stopped the regular imports of Gene Expression Omnibus (GEO) data into ArrayExpress. This may not be the latest version of this experiment.
E-GEOD-70728 - Role of the histone demethylase KDM2B in hematopoietic homeostasis and malignancies [RNA-seq]
Released on 22 February 2016, last updated on 27 February 2016
Development of the hematopoietic system is dynamically controlled by the interplay of transcriptional and epigenetic networks to determine cellular identity. Those networks are critical for homeostasis and frequently dysregulated in leukemias. We identified histone demethylase Kdm2b as a critical regulator of definitive hematopoiesis and lineage specification of hematopoietic stem and progenitor cells (HSPCs). RNA sequencing in murine HSPCs and genome-wide chromatin immunoprecipitation studies in human leukemias revealed that Kdm2b regulates differentiation, lineage choice, cytokine signaling, and quiescence. Comparison of gene expression in wild-type and knockout HSPCs
RNA-seq of coding RNA
Alexandros Tzatsos, Yan Kai
Histone demethylase KDM2B regulates lineage commitment in normal and malignant hematopoiesis. Andricovich J, Kai Y, Peng W, Foudi A, Tzatsos A. , PMID:26808549