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E-GEOD-70098 - The histone H3 lysine 4 presenter WDR5 induces N-Myc target gene transcription and promotes neuroblastoma [ChIP-Seq]

Status
Released on 31 December 2015, last updated on 2 January 2016
Organism
Homo sapiens
Samples (6)
Protocols (3)
Description
WDR5 is an important co-factor for N-Myc-regulated transcriptional activation and tumorigenesis Using ChIP-Seq, We profiled key epigenetic marks H3K4 trimethylation in BE(2)-C neuroblastoma cells transfected with control siRNA or WDR5 siRNA-1 at N-Myc target gene promoters The results showed knockdown WDR5 significantly reduced H3K4me3 at 93.2% of N-Myc binding promoters, but only at 53.5% of N-Myc non-binding promoters. Identification of Histone H3K4 trimethylation and N-Myc binding sites in BE(2)-C cells transfected with control siRNA or WDR5 siRNA-1.
Experiment type
ChIP-seq 
Contacts
Tao Liu, Yuting Sun
MINSEQE
Exp. designProtocolsVariablesProcessedSeq. reads
Files
Investigation descriptionE-GEOD-70098.idf.txt
Sample and data relationshipE-GEOD-70098.sdrf.txt
Additional data (1)E-GEOD-70098.additional.1.zip
Links