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E-GEOD-69889 - Genome-wide Circadian Control of Transcription at Active Enhancers Regulates Insulin Secretion and Diabetes Risk

Status
Released on 10 November 2015, last updated on 1 December 2015
Organism
Homo sapiens, Mus musculus
Samples (60)
Protocols (5)
Description
The molecular clock is a transcriptional oscillator present in brain and peripheral cells that coordinates behavior and physiology with the solar cycle. Here we reveal that the clock gates insulin secretion through genome-wide transcriptional control of the pancreatic exocyst across species. Clock transcription factors bind to unique enhancer sites in cycling genes in beta cells that diverge from those in liver, revealing the dynamics of inter-tissue clock control of genomic and physiologic processes important in glucose homeostasis. Transcriptome profiling in mouse and human islets at serial 4-hour time intervals by polyA RNA-Seq
Experiment type
RNA-seq of coding RNA 
Contacts
Mark Perelis <mperelis@u.northwestern.edu>, Biliana Marcheva, Grant D Barish, Joseph Bass
Citation
MINSEQE
Exp. designProtocolsVariablesProcessedSeq. reads
Files
Investigation descriptionE-GEOD-69889.idf.txt
Sample and data relationshipE-GEOD-69889.sdrf.txt
Additional data (1)E-GEOD-69889.additional.1.zip
Links