Please note that we have stopped the regular imports of Gene Expression Omnibus (GEO) data into ArrayExpress. This may not be the latest version of this experiment.
E-GEOD-69777 - Cistrome of the Aldosterone-activated Mineralocorticoid Receptor in Human Renal Cells
Released on 12 June 2015, last updated on 21 June 2015
Aldosterone, the main mineralocorticoid hormone in Humans, has a major role in maintaining the hemo-electrolytique homeostasis, by acting in the distal part of nephron. This steroid hormone mainly acts through its binding to a ligand-induced transcription factor, the mineralocorticoid receptor (MR). MR binds to specific genomic sequences, where it recruits transcriptional coregulators, to activate or repress target gene transcription. The aim of this work was to access the whole aldosterone-dependand MR target genes, by comparing sequenced data from aldosterone or vehicle-treated samples. Anti-MR ChIP-seq in Human Kidney GFP-hMR cells treated with vehicle or Aldosterone.
Florian Le Billan <email@example.com>, Juliette Pouch, Junaid A Khan, Jérôme Bouligand, Jérôme Fagart, Khadija Lamribet, Marc Lombès, Say Viengchareun, Sophie Lemoine
Cistrome of the aldosterone-activated mineralocorticoid receptor in human renal cells. Le Billan F, Khan JA, Lamribet K, Viengchareun S, Bouligand J, Fagart J, Lombï¿½s M.