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E-GEOD-6797 - 46,XY sex reversed females with complete androgen insensitivity syndrome

Status
Submitted on 18 January 2007, released on 25 June 2010, last updated on 2 May 2014
Organism
Homo sapiens
Samples (30)
Arrays (3)
Protocols (15)
Description
This gene set contains skin fibroblasts from either labia majora of 46,XY sex reversed females having complete androgen insensitivity syndrome due to inactivation mutations of the androgen receptor gene and from the scrotum of normal males. Both, labia majora and scrotum origin from the same embryological anlagen, the labioscrotal swellings. The phenotypic difference is due to androgen dependent virilization in males. This is not possible in 46,XY patients with complete androgen insensitivity syndrome because the androgen receptor pathway is knocked out. A cell type comparison design experiment design type compares cells of different type for example different cell lines. Cell Line: genital skin fibroblasts from different locations mutant line: normal 46,XY male and 46,XY sex reversed female due to inactivating mutations of the androgen receptor gene Computed
Experiment type
unknown experiment type 
Contact
Citation
Intrinsic androgen-dependent gene expression patterns revealed by comparison of genital fibroblasts from normal males and individuals with complete and partial androgen insensitivity syndrome. Holterhus PM, Deppe U, Werner R, Richter-Unruh A, Bebermeier JH, Wünsch L, Krege S, Schweikert HU, Demeter J, Riepe F, Hiort O, Brooks JD.
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-GEOD-6797.idf.txt
Sample and data relationshipE-GEOD-6797.sdrf.txt
Processed data (1)E-GEOD-6797.processed.1.zip
Array designsA-GEOD-3335.adf.txt, A-GEOD-3526.adf.txt, A-GEOD-4761.adf.txt
Links