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E-GEOD-66048 - Transcription profiling by array of uveal melanoma cell lines with wild type and mutant G-proteins (GNAQ or GNA11) in response to treatment with BRAD4 inhibitor JQ1

Status
Released on 19 February 2015, last updated on 30 April 2015
Organism
Homo sapiens
Samples (48)
Array (1)
Protocols (7)
Description
G protein alpha q and 11 are mutated in 80% of uveal melanoma. We observed that treatment with the BRD4 inhibitor JQ1 resulted in different phenotypic responses in G-protein mutant uveal melanoma cell lines and wild type uveal melanoma cell lines. We used microarrarys to profile the gene expression changes occuring in wild type and mutant cell lines in response to treament with JQ1 Uveal melanoma cells were profiled in triplicate on Affymetrix Human Genome U133A 2.0 Array arrays per manufacturer's instructions
Experiment type
transcription profiling by array 
Contacts
Grazia Ambrosini <ga2391@columbia.edu>, Ashley D Sawle, Elgilda Musi, Gary K Schwartz
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-GEOD-66048.idf.txt
Sample and data relationshipE-GEOD-66048.sdrf.txt
Raw data (1)E-GEOD-66048.raw.1.zip
Processed data (1)E-GEOD-66048.processed.1.zip
Array designA-AFFY-37.adf.txt
Links