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E-GEOD-64400 - Transmitted/founder hepatitis C viruses induce cell type- and genotype-specific differences in innate signaling within the liver

Status
Released on 20 December 2014, last updated on 2 January 2015
Organism
Homo sapiens
Samples (3)
Array (1)
Protocols (7)
Description
Primary human hepatocytes (PHHs) are a liver-specific cell subtype, and we have shown that these cells respond in a unique manner to the introduction of hepatitis C viral RNA (HCV vRNA) derived from different genotypes of the virus. We used microarray to analyze the transcriptional differences between the PHHs exposed to the different genotypes of HCV to further shed light on their differential effects on HCV innate immune responses in vitro HCV vRNA from either genotype 3a HCV or genotype 1a HCV was introduced into the PHH cells for 8 hours. Total RNA was then harvested to determine transcriptional differences.
Experiment type
transcription profiling by array 
Contacts
Michael Edwards <michael.edwards@ucdenver.edu>, Amy E Stone, Angela M Mitchell, George M Shaw, Hugo R Rosen, Hui Li, Kimberly Ballinger, Linling Cheng, Lucy Golden-Mason, Mark Stoddard, Michael G Edwards, Salman Khetani
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-GEOD-64400.idf.txt
Sample and data relationshipE-GEOD-64400.sdrf.txt
Raw data (1)E-GEOD-64400.raw.1.zip
Processed data (1)E-GEOD-64400.processed.1.zip
Array designA-GEOD-16686.adf.txt
Links