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E-GEOD-63755 - Defective removal of ribonucleotides from DNA promotes systemic autoimmunity

Status
Released on 15 December 2014, last updated on 2 January 2015
Organism
Homo sapiens
Samples (7)
Protocols (3)
Description
Constitutive low level DNA damage in RNASEH2 deficiency is linked to innate immune activation. Hierarchical clustering of over 16000 transcripts revealed remarkably similar profiles in patients with lupus erythematosus and patients with AGS with up-regulation of genes involved in DNA damage signaling and type I-IFN signaling. Comparison of transcriptional profiles of native RNASEH2-deficient patient fibroblasts with wild type cells.
Experiment type
RNA-seq of coding RNA 
Contacts
Min Ae Lee-Kirsch <MinAe.Lee-Kirsch@uniklinikum-dresden.de>, Alice Lorenzi, Andrea Leitch, Andreas Dahl, Andrew Jackson, Anja Bauernfeind, Annegret Kuhn, Annette Bley, Axel Roers, Barbara Kind, Christine Wolf, Claudia Günther, Claudia Krug, David Morris, Deborah C Graham, Dimitra Alexopoulou, Doryen Bubeck, Elisabeth Mangold, Elizabeth Blackburn, Franziska Schmidt, Georgia Ramantani, Inga Melchers, John Isaacs, Karsten Conrad, Katy Astell, Kirsten Lüthke, Leonore Unger, Louise Bicknell, Manfred Gahr, Manuel Martinez-Bueno, Markus Nöthen, Marta Alarcon-Riquelme, Martin Aringer, Martin Reijns, Min A Lee-Kirsch, Nicole Berndt, Norbert Hübner, Osvaldo Chara, Sarah Koss, Sophia Blum, Stefanie Kretschmer, Stuart Ralston, Timothy Vyse, Torsten Witte, Victoria Tüngler, Young A Lee
MINSEQE
Exp. designProtocolsVariablesProcessedSeq. reads
Files
Investigation descriptionE-GEOD-63755.idf.txt
Sample and data relationshipE-GEOD-63755.sdrf.txt
Additional data (1)E-GEOD-63755.additional.1.zip
Links