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E-GEOD-63659 - Transcriptomic Changes in TGF-β1 Differentiated and PGE2 Dedifferentiated Myofibroblasts

Status
Released on 30 June 2015, last updated on 19 August 2015
Organism
Homo sapiens
Samples (12)
Array (1)
Protocols (7)
Description
These data show that the genes that distinguish myofibroblasts from fibroblasts are myriad, and that some genes not traditionally associated with myofibroblast differentiation may serve as novel therapeutic targets for fibrosing disorders. Gene expression levels were assessed from total RNA on the Affymetrix U219 microarray. Here, we use transforming growth factor-β1 (TGF-β1) and prostaglandin E2 (PGE2), which has recently been shown to reverse myofibroblast differentiation, to investigate the transcriptomic changes that occur during TGF-β1-induced differentiation and PGE2-induced de-differentiation of myofibroblasts.
Experiment type
transcription profiling by array 
Contacts
Richard C McEachin <mceachin@umich.edu>, Richard McEachin, Steven Huang
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-GEOD-63659.idf.txt
Sample and data relationshipE-GEOD-63659.sdrf.txt
Raw data (1)E-GEOD-63659.raw.1.zip
Processed data (1)E-GEOD-63659.processed.1.zip
Array designA-GEOD-13667.adf.txt
Links