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E-GEOD-63548 - Expression profiling of lymph nodes in tuberculosis patients reveal inflammatory milieu at site of infection

Status
Released on 1 March 2015, last updated on 7 March 2015
Organism
Homo sapiens
Samples (26)
Array (1)
Protocols (7)
Description
Extrapulmonary manifestations constitute 15-20% of tuberculosis cases, with lymph node as the most common site. Understanding of disease etiology is limited due to the lack of understanding patients’ infected tissue milieu. This study was designed to perform global transcriptome analysis of lymph node tissues from healthy individuals and Mycobacterium tuberculosis infected lymph nodes of patients to decipher the local response of infected tissue. This study was designed to elucidate gene expression signatures in the event of Lymph Node Tuberculosis. Total RNA was extracted from lymph node tissue samples of LNTB patients in BSL3 facility and together with healthy lymph node RNA samples (commercially purchased) their global transcriptome profiling was performed using Illumina HumanHT-12 V4 expression beadchip.
Experiment type
transcription profiling by array 
Contacts
Yogendra Singh <ysingh@igib.res.in>, Abhijit Maji, Anupam K Mondal, Richa Misra
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-GEOD-63548.idf.txt
Sample and data relationshipE-GEOD-63548.sdrf.txt
Raw data (1)E-GEOD-63548.raw.1.zip
Processed data (1)E-GEOD-63548.processed.1.zip
Additional data (1)E-GEOD-63548.additional.1.zip
Array designA-GEOD-10558.adf.txt
Links