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E-GEOD-62878 - Expression profiles of liver tissues from wild-type and AID transgenic mice exposed to thioacetamide hepatotoxicity

Status
Released on 10 July 2015, last updated on 19 August 2015
Organism
Mus musculus
Samples (4)
Array (1)
Protocols (5)
Description
AID is an intrinsic DNA mutator enzyme and contributes to tumorigenesis through the accumulation of genetic aberrations. To examine whether mutagenesis induced by AID during inflammation-associated hepatocarcinogenesis depends on the transcriptional levels of the target genes, we performed the gene expression profiling of liver tissues from AID transgenic mice and wild-type mice with and without thioacetamide treatment. AID transgenic mice and wild-type mice were administered with thioacetamide in drinking water for 6 months, and the gene expression levels of their livers are compared.
Experiment type
transcription profiling by array 
Contacts
Citation
Hepatic inflammation facilitates transcription-associated mutagenesis via AID activity and enhances liver tumorigenesis. Matsumoto T, Shimizu T, Nishijima N, Ikeda A, Eso Y, Matsumoto Y, Chiba T, Marusawa H.
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-GEOD-62878.idf.txt
Sample and data relationshipE-GEOD-62878.sdrf.txt
Raw data (1)E-GEOD-62878.raw.1.zip
Processed data (1)E-GEOD-62878.processed.1.zip
Array designA-GEOD-10333.adf.txt
Links