Please note that we have stopped the regular imports of Gene Expression Omnibus (GEO) data into ArrayExpress. This may not be the latest version of this experiment.
E-GEOD-61471 - Cooperativity, specificity and evolutionary stability of Polycomb targeting in Drosophila
Released on 20 October 2014, last updated on 25 October 2014
We report the evolutionary behaviour of Polycomb group proteins, their recruitment factors and their underlying sequences by performing ChIP-seq analysis in 4-5 different Drosophila species (GSE60428) and HiC analysis in Drosophila melanogaster. We demonstrate an extremely high conservation of Polycomb repressive domains across Drosophila species We validate few cases of PRE divergence that shows that cis-driven PRE evolution is a rare event. We further show that PHO recruitment to Polycomb domains is evolutionarily robust to motif changes and that PRC1 stabilizes binding of its key recruiter HiC experiments in wild type drosophila embryos
Jia-Ming Chang <email@example.com>, Amos Tanay, Aubin Thomas, Bernd Schuettengruber, Eitan Yaffe, Giacomo Cavalli, Hugues Parrinello, Marianne Entrevan, Noa O Elkayam, Shani Stern, Tom Sexton
Cooperativity, specificity, and evolutionary stability of polycomb targeting in Drosophila. Schuettengruber B, Oded Elkayam N, Sexton T, Entrevan M, Stern S, Thomas A, Yaffe E, Parrinello H, Tanay A, Cavalli G. , PMID:25284790