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E-GEOD-60428 - Cooperativity, specificity and evolutionary stability of Polycomb targeting in Drosophila

Released on 20 October 2014, last updated on 25 October 2014
Drosophila melanogaster, Drosophila pseudoobscura, Drosophila simulans, Drosophila virilis, Drosophila yakuba
Samples (64)
Protocols (1)
We report the evolutionary behaviour of Polycomb group proteins, their recruitment factors and their underlying sequences by performing ChIP-seq analysis in 4-5 different Drosophila species. We demonstrate an extremely high conservation of Polycomb repressive domains across Drosophila species We validate few cases of PRE divergence that shows that cis-driven PRE evolution is a rare event. We further show that PHO recruitment to Polycomb domains is evolutionarily robust to motif changes and that PRC1 stabilizes binding of its key recruiter ChIP-seq analysis of histone marks and chromatin associated factors across 4-5 Drosophila species
Experiment type
Bernd Schuettengruber <>, Amos Tanay, Aubin Thomas, Eitan Yaffe, Giacomo Cavalli, Hugues Parrinello, Marianne Entrevan, Noa O Elkayam, Shani Stern, Tom Sexton
Cooperativity, specificity, and evolutionary stability of polycomb targeting in Drosophila. Schuettengruber B, Oded Elkayam N, Sexton T, Entrevan M, Stern S, Thomas A, Yaffe E, Parrinello H, Tanay A, Cavalli G. , PMID:25284790
Exp. designProtocolsVariablesProcessedSeq. reads