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E-GEOD-58659 - Transcript profile comparison of Zbtb20-sufficient and Zbtb20-deficient polyclonal bone marrow plasma cells

Released on 19 June 2014, last updated on 29 June 2014
Mus musculus
Samples (8)
Array (1)
Protocols (7)
ZBTB20 is an adjuvant-specific factor for long-term antibody responses. This factor is critical for maintaining long-lived plasma cells in alum-adjuvanted antibody responses but is dispensable for TLR ligand-adjuvanted responses. To identify the functions of ZBTB20 in long-lived plasma cells, we performed microarray analysis on Zbtb20-sufficient and Zbtb20-deficient polyclonal bone marrow plasma cells under the assumption that ZBTB20 regulates relevant targets in all long-lived plasma cells, irrespective of their mode of formation. Chimeras were generated using Zbtb20-sufficient (WT) or Zbtb20-deficient (TRAP) E14.5 fetal livers. 3-4 months after reconstitution, donor bone marrow B220low/-CD138+ cells (4 replicates per genotype) were purified via FACS for microarray. In total, 8 samples, 4 for each genotype, were included in this study.
Experiment type
transcription profiling by array 
Yinan Wang <>, Deepta Bhattacharya
Investigation descriptionE-GEOD-58659.idf.txt
Sample and data relationshipE-GEOD-58659.sdrf.txt
Raw data (1)
Processed data (1)
Array designA-AFFY-130.adf.txt