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E-GEOD-58515 - Gene expression of Bone marrow-derived macrophages isolated in ERR-alpha knock-out mice

Status
Released on 17 June 2014, last updated on 20 June 2014
Organism
Mus musculus
Samples (4)
Array (1)
Protocols (7)
Description
We investigated the molecular mechanisms by which ERRα negatively regulates TLR-signaling pathways. To examine this, we performed global gene expression analysis of ERRα+/+ and ERRα-/- BMDMs after LPS stimulation. Microarray analysis revealed that several genes encoding various TLR-negative regulators were downregulated in LPS-stimulated ERRα-/- BMDMs, when compared with ERRα+/+ BMDMs Bone marrow-derived macrophages were isolated in 6~8 week old male C57BL6 mice and then divided into 4 groups 1) Solvent control-treated ERRα+/+ BMDM 2) LPS-treated ERRα+/+ BMDM 3) Solvent control-treated ERRα-/- BMDM 4) LPS-treated ERRα-/- BMDM
Experiment type
transcription profiling by array 
Contacts
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-GEOD-58515.idf.txt
Sample and data relationshipE-GEOD-58515.sdrf.txt
Raw data (1)E-GEOD-58515.raw.1.zip
Processed data (1)E-GEOD-58515.processed.1.zip
Array designA-GEOD-13912.adf.txt
Links