E-GEOD-5838 - Transcription profiling of human transplanted intestine before signs of rejects and when there was signs of actue cellular rejection

Status
Submitted on 14 September 2006, released on 3 April 2008, last updated on 10 June 2011
Organism
Homo sapiens
Samples (6)
Array (1)
Protocols (4)
Description
Acute cellular rejection (ACR) is the major cause of intestinal graft loss. Little is known about the genetic response occurring in small bowel transplantation (SBTx) during ACR. We report the case of a 44 year-old female with short gut syndrome following multiple surgeries for familial adenomatous polyposis that underwent living-related SBTx. We obtained for the first time a gene expression profile of the intestinal graft during ACR. Microarray analysis revealed increased transcript levels for genes that match identically to an IFN? signature reported for activated plasmacytoid dendritic cells and T-cell chemotaxis and cytolysis correlating with the diagnosis of ACR. Experiment Overall Design: sam1, sam2, sam3 (without signs of rejection) Experiment Overall Design: sam4, sam5, sam6 (with signs and symptoms of rejection , histology showed increasing lymphocyte infiltration in the lamina propria and epithelium)
Experiment types
transcription profiling by array, unknown experiment type
Contact
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-GEOD-5838.idf.txt
Sample and data relationshipE-GEOD-5838.sdrf.txt
Processed data (1)E-GEOD-5838.processed.1.zip
Additional data (1)E-GEOD-5838.additional.1.zip
Array designA-AFFY-44.adf.txt
Links