E-GEOD-58359 - Gene expression changes after loss of Hoxa9 in transformed HSCs [HOXA9 RNA-seq]
Released on 11 June 2014, last updated on 14 August 2014
Characterization of gene expression changes 72 hours after withdrawal of tamoxifen in murine hematopoietic progenitors transformed by Hoxa9-ER/Meis1 using RNAseq. In the presence of tamoxifen (4OHT), Hoxa9-ER localizes to the nucleus of cells allowing for transformation, while withdrawal of 4OHT (culture in EtOH) leads to loss of nuclear Hoxa9-ER. Loss of Hoxa9-ER leads to a decrease in cellular proliferation and differentiation along the myeloid lineage. Examination of gene expression by RNAseq in two conditions in biological replicates.
RNA-seq of coding RNA
Jay L. Hess <email@example.com>, Jay L Hess