Please note that we have stopped the regular imports of Gene Expression Omnibus (GEO) data into ArrayExpress. This may not be the latest version of this experiment.
E-GEOD-58211 - Expression data of chronic lymphocytic leukemia patient samples from the REACH study
Released on 30 July 2014, last updated on 2 August 2014
We assessed genome-wide expression of available pretreatment specimens from CLL patients enrolled in REACH, a study of fludarabine and cyclophosphamide FC or R-FC (addition of rituximab to FC) in relapsed CLL, to understand the disease heterogeneity and explore genes that may be prognostic or predictive of benefit from R-FC treatment. REACH (NCT00090051) was registered at www.clinicaltrials.gov. This dataset supports the manuscript "PTK2 expression and immunochemotherapy outcome in chronic lymphocytic leukemia" by Weisser et al. 300 available pretreatment specimens from patients enrolled in REACH trial were analyzed. Additional contributers: REACH study investigators and patients
transcription profiling by array
Anna Dmoszynska, Annika Dufour, Boris V Afanasiev, Christian H Geisler, David Dornan, Giuseppe Palermo, Guillemette Duchateau-Nguyen, Isabelle Bence-Bruckler, Loree Larratt, Marco Montillo, Martin Weisser, Michael K Wenger, Nancy Valente, Nancy Yu, Philippe Solal-Celigny, Ru-Fang Yeh, Sergey I Moiseev, Susanna Y Stinson, Tadeusz Robak, Tri O Nguyen, Viktor A Rossiev, Xiaoyan Shi