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E-GEOD-57966 - Microtubule Affinity-Regulating Kinase 2 is associated with DNA damage response and cisplatin resistance in non-small cell lung cancer

Released on 22 June 2015, last updated on 27 June 2015
Homo sapiens
Samples (12)
Array (1)
Protocols (5)
MARK2 expression is associated with the malignant phenotype, expression of DNA repair components, NF-κB inhibition and cell cycle transcription factors in lung cancer cells We used microarrays to determine the global gene expression pattern associated with knockdown of MARK2 3 lung cancer cell lines overexpressing MARK2 have been selected to assess the gene expression pattern after MARK2 knockdown. RNA extraction and hybridization on Affymetrix microarrays have been done on 2 biological replicates for each line (H1993, H1693 and H1650) after shRNA lentiviral transduction and compared with respective contols using the empty vector pLKO.
Experiment type
transcription profiling by array 
Adi F Gazdar, Daiana D Becker-Santos, Emily A Vucic, Kelsie L Thu, Larissa A Pikor, Mitra Mosslemi, Roland Hubaux, Sonia H Kung, Stephen Lam, Victor D Martinez, Wan L Lam
Microtubule affinity-regulating kinase 2 is associated with DNA damage response and cisplatin resistance in non-small cell lung cancer. Hubaux R, Thu KL, Vucic EA, Pikor LA, Kung SH, Martinez VD, Mosslemi M, Becker-Santos DD, Gazdar AF, Lam S, Lam WL.
Investigation descriptionE-GEOD-57966.idf.txt
Sample and data relationshipE-GEOD-57966.sdrf.txt
Raw data (1)
Processed data (1)
Array designA-GEOD-15207.adf.txt