Please note that we have stopped the regular imports of Gene Expression Omnibus (GEO) data into ArrayExpress. This may not be the latest version of this experiment.
E-GEOD-57966 - Microtubule Affinity-Regulating Kinase 2 is associated with DNA damage response and cisplatin resistance in non-small cell lung cancer
Released on 22 June 2015, last updated on 27 June 2015
MARK2 expression is associated with the malignant phenotype, expression of DNA repair components, NF-κB inhibition and cell cycle transcription factors in lung cancer cells We used microarrays to determine the global gene expression pattern associated with knockdown of MARK2 3 lung cancer cell lines overexpressing MARK2 have been selected to assess the gene expression pattern after MARK2 knockdown. RNA extraction and hybridization on Affymetrix microarrays have been done on 2 biological replicates for each line (H1993, H1693 and H1650) after shRNA lentiviral transduction and compared with respective contols using the empty vector pLKO.
transcription profiling by array
Adi F Gazdar, Daiana D Becker-Santos, Emily A Vucic, Kelsie L Thu, Larissa A Pikor, Mitra Mosslemi, Roland Hubaux, Sonia H Kung, Stephen Lam, Victor D Martinez, Wan L Lam
Microtubule affinity-regulating kinase 2 is associated with DNA damage response and cisplatin resistance in non-small cell lung cancer. Hubaux R, Thu KL, Vucic EA, Pikor LA, Kung SH, Martinez VD, Mosslemi M, Becker-Santos DD, Gazdar AF, Lam S, Lam WL.