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E-GEOD-5788 - Transcription profiling of human prolymphocytic leukemina T-cells and normal T-cells

Status
Submitted on 7 September 2006, released on 10 December 2008, last updated on 27 March 2012
Organism
Homo sapiens
Samples (14)
Array (1)
Protocols (5)
Description
T-cell prolymphocytic leukemina (T-PLL) is an agressive lymphoma derived from mature T-cells, which is in most cases characterized by the presence of an inv(14)(q11q32) and a characteristic pattern of secondary chromosomal abberations. We used microarrays to compare the transcriptomes of eight immunomagnetically purified CD3+ normal donor derived peripheral blood cells with five highly purified inv(14)-positive T-PLL blood samples. Experiment Overall Design: Purified T-PLL cells and normal T-cells were analyzed on microarrays to identify differentially expressed genes. High-resolution copy number determination using SNP-chip technology and FISH in twelve inv(14)-positive T-PLL showed that differentially expressed genes clustered significantly in regions affectd by recurrent chromosomal imbalances.
Experiment types
transcription profiling by array, unknown experiment type
Contact
Citation
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-GEOD-5788.idf.txt
Sample and data relationshipE-GEOD-5788.sdrf.txt
Raw data (1)E-GEOD-5788.raw.1.zip
Processed data (1)E-GEOD-5788.processed.1.zip
Array designA-AFFY-33.adf.txt
R ExpressionSetE-GEOD-5788.eSet.r
Links