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E-GEOD-5788 - Transcription profiling of human prolymphocytic leukemina T-cells and normal T-cells

Submitted on 7 September 2006, released on 10 December 2008, last updated on 27 March 2012
Homo sapiens
Samples (14)
Array (1)
Protocols (5)
T-cell prolymphocytic leukemina (T-PLL) is an agressive lymphoma derived from mature T-cells, which is in most cases characterized by the presence of an inv(14)(q11q32) and a characteristic pattern of secondary chromosomal abberations. We used microarrays to compare the transcriptomes of eight immunomagnetically purified CD3+ normal donor derived peripheral blood cells with five highly purified inv(14)-positive T-PLL blood samples. Experiment Overall Design: Purified T-PLL cells and normal T-cells were analyzed on microarrays to identify differentially expressed genes. High-resolution copy number determination using SNP-chip technology and FISH in twelve inv(14)-positive T-PLL showed that differentially expressed genes clustered significantly in regions affectd by recurrent chromosomal imbalances.
Experiment types
transcription profiling by array, unknown experiment type
Investigation descriptionE-GEOD-5788.idf.txt
Sample and data relationshipE-GEOD-5788.sdrf.txt
Raw data (1)
Processed data (1)
Array designA-AFFY-33.adf.txt
R ExpressionSetE-GEOD-5788.eSet.r