E-GEOD-56489 - Prospective Evaluation of Whole Genome MicroRNA Expression Profiling in Childhood Acute Lymphoblastic Leukemia

Status
Released on 5 April 2014, last updated on 3 June 2014
Organism
Homo sapiens
Samples (57)
Array (1)
Protocols (6)
Description
Dysregulation of microRNA (miRNA) expression contributes to the pathogenesis of several clinical conditions. The aim of this study is to evaluate the associations between miRNAs and childhood acute lymphoblastic leukemia (ALL) to discover their clinical and therapeutic implications. Forty-three children with ALL and 14 age-matched healthy controls were included in the study. MicroRNA microarray expression profiling was used for peripheral blood and bone marrow samples. Aberrant miRNA expressions associated with the diagnosis and outcome were prospectively evaluated. Confirmation analysis was performed by real time RT-PCR. miR-128, miR-146a, miR-155, miR-181a, miR-195 were significantly dysregulated in ALL patients at day 0. Following a six-month treatment period, the change in miRNA levels was determined by real time RT-PCR and expression of miR-146a, miR-155, miR-181a, miR-195 significantly decreased. Forty-three children with ALL and 14 age-matched healthy controls were included in the study.
Experiment type
transcription profiling by array 
Contacts
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-GEOD-56489.idf.txt
Sample and data relationshipE-GEOD-56489.sdrf.txt
Raw data (1)E-GEOD-56489.raw.1.zip
Processed data (1)E-GEOD-56489.processed.1.zip
Array designA-GEOD-14132.adf.txt
Links