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E-GEOD-55998 - Cellular and Molecular Immune Profiles in Renal Transplant Recipients after Conversion from Tacrolimus to Sirolimus

Status
Released on 17 September 2014, last updated on 20 September 2014
Organism
Homo sapiens
Samples (18)
Array (1)
Protocols (5)
Description
Tacrolimus and Sirolimus are commonly used to maintain immunosuppression in kidney transplantation. However, their effects on immune cells and allograft molecular profiles have not been elucidated. Here we characterized the effects of Tacrolimus to Sirolimus conversion on frequency and function of T cells, and on graft molecular profiles. Samples from 30 renal transplant recipients in a randomized trial of late Sirolimus conversion (n=18) vs. Tacrolimus maintenance (n=12) were utilized. Peripheral blood was collected at 0- 6- 12 and 24-months post-randomization. This dataset only contains the 18 arrays corresponding to patients treated with Sirolimus.
Experiment type
transcription profiling by array 
Contacts
Catherine Dumur <geo@ncbi.nlm.nih.gov>, Catherine I Dumur, Daniel Maluf, Valeria Mas
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-GEOD-55998.idf.txt
Sample and data relationshipE-GEOD-55998.sdrf.txt
Raw data (1)E-GEOD-55998.raw.1.zip
Processed data (1)E-GEOD-55998.processed.1.zip
Array designA-AFFY-37.adf.txt
Links