E-GEOD-5583 - Transcription profiling by array of embryonic stem cells from wild type and histone deacetylase 1 (HDAC1) knock out mice
Released on 13 November 2007, last updated on 30 April 2015
Histone deacetylase 1 (HDAC1) is an enzyme that promotes deacetylation of acetylated lysine residues in histones and other proteins. Histone acetylation is often associated with gene activation and expression. Los of HDAC1 leads to severe problems in development and proliferation. Moreover, it seems to be the major histone deacetylase in mouse embryonic stem cells. We used microarrays to identify putative HDAC1 target genes. Experiment Overall Design: Wild type and HDAC1 mouse embryonic stem cell, originating from same litter, were used for RNA extraction and hybridization on Affymetrix microarrays.
transcription profiling by array, co-expression, individual genetic characteristics
Negative and positive regulation of gene expression by mouse histone deacetylase 1. Gordin Zupkovitz, Julia Tischler, Markus Posch, Iwona Sadzak, Katrin Ramsauer, Gerda Egger, Reinhard Grausenburger, Norbert Schweifer, Susanna Chiocca, Thomas Decker, Christian Seiser.