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E-GEOD-55594 - Gene expression profiling of breast fibroadenomas

Status
Released on 13 June 2014, last updated on 21 June 2014
Organism
Homo sapiens
Samples (10)
Array (1)
Protocols (5)
Description
Fibroadenomas are the most common benign breast tumors in women under 30. Unlike their malignant counterparts, relatively molecular profiling has been done on fibroadenomas. Here we performed gene expression profiling on ten fibroadenomas in order to better characterize these tumors. Through targeted amplicon sequencing, we have found that six of these tumors have MED12 mutations. Here, we show that the MED12 mutations, among others, are associated with activated estrogen signaling, as well as increased invasiveness through upregulation of ECM remodelling genes. Microarray gene expression profiling was performed on 10 breast fibroadenomas and a combination of unsupervised and supervised clustering was performed to determine any differentially activated pathways between samples with mutated and non-mutated MED12.
Experiment type
transcription profiling by array 
Contacts
Weng Khong Lim <wengkhong.lim@duke-nus.edu.sg>, Bin T Teh, Choon K Ong, Jing Tan, Weng K Lim
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-GEOD-55594.idf.txt
Sample and data relationshipE-GEOD-55594.sdrf.txt
Raw data (1)E-GEOD-55594.raw.1.zip
Processed data (1)E-GEOD-55594.processed.1.zip
Array designA-GEOD-17811.adf.txt
Links