E-GEOD-54884 - Human blood monocyte response to IL-17A in culture

Released on 30 April 2014, last updated on 3 June 2014
Homo sapiens
Samples (6)
Array (1)
Protocols (5)
The levels of IL-17 are elevated in the serum of psoriasis patients. However, the effects of IL-17 on circulating leukocytes bearing the IL-17 receptors are not fully understood. Of particular interest are monocytes, as the activation and recruitment of effector monocytes underlies the pathobiology of a number systemic inflammatory diseases, including psoriasis co-morbidities, such as atherosclerosis, metabolic regulation in adipose tissue and psoriatic arthritis. Human monocytes highly express both IL-17RA and IL-17RC and chemotraffick in response to IL-17. We explored the impact of IL-17 on blood monocytes. Using cDNA microarray, , we molecularly characterized how human blood monocytes respond to IL-17A in vitro. total RNA was extratced from CD14+ monocytes (isolated from human blood) after 24hr culture with or without IL-17A (200ng/mL)
Experiment type
transcription profiling by array 
Mayte Suarez-Farinas <farinam@rockefeller.edu>, Claire Q Wang, James G Krueger, Kristine E Nograles, Mayte Suárez-Fariñas
Investigation descriptionE-GEOD-54884.idf.txt
Sample and data relationshipE-GEOD-54884.sdrf.txt
Raw data (1)E-GEOD-54884.raw.1.zip
Processed data (1)E-GEOD-54884.processed.1.zip
Array designA-AFFY-37.adf.txt