Please note that we have stopped the regular imports of Gene Expression Omnibus (GEO) data into ArrayExpress. This may not be the latest version of this experiment.
E-GEOD-54812 - WT and FcgKO peritoneal MF response to IFNg
Released on 1 March 2014, last updated on 3 June 2014
Emerging data suggest that many immunoreceptors, all of which use a conserved ITAM-module for their signaling, can couple with members of additional classes of membrane receptors to deliver unique signal(s) to the cell. Using functional and gene expression analysis we describe the role for the tonic signaling through Fcg-chain, the major ITAM-module of the innate immune system, in modifying cytokine responses in MF. Peritoneal MF were left unstimulated or were stimulated in duplicates for 6 hrs with IFNγ. cDNA was analyzed using 8-sample Mouse Ref-8 v2.0 Illumina array. Expressed genes were defined as those with p<0.05, and their relative expression values were calculated using average of two WT unstimulated samples as calibrator.
transcription profiling by array
Ruslan Medzhitov <email@example.com>, Medzhitov Ruslan